In vitro antitumor activity
WebAug 17, 2001 · DOI: 10.1016/S0014-5793(01)02736-3 Corpus ID: 30714485; In vitro antitumor activity of cerivastatin, a novel and potent HMG‐CoA reductase inhibitor @article{Feleszko2001InVA, title={In vitro antitumor activity of cerivastatin, a novel and potent HMG‐CoA reductase inhibitor}, author={Wojciech Feleszko and Izabela Mlynarczuk … WebNov 14, 2014 · Compounds 7b,d,f and 8c,f showed remarkable antitumor activity against 58 cancer cell lines, with the most important GI 50 values from in vitro assays ranging from 0.48 to 1.66 μM. The 2-pyrazoline derivatives bearing the 4-aryloxy-7-chloroquinoline fragment are thus considered to be useful leads for the rational design of new antitumor …
In vitro antitumor activity
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WebJul 1, 2024 · Intracranial antitumor activity of repotrectinib was evaluated in a brain-metastasis mouse model. Results: Repotrectinib potently inhibited in vitro and in vivo tumor growth and ROS1 downstream signal in treatment-naïve YU1078 compared with clinically available crizotinib, ceritinib, and entrectinib. WebThese cubosomes were characterized for size, zeta potential, entrapment efficiency, small angle X-ray diffraction, in vitro release, in vitro cytotoxicity, cellular uptake, and antitumor activity. Particle size of cubosomes was 220 ± 3.6 nm with almost neutral zeta potential - 5 ± 1.2 mV and X-ray measurements confirmed the existence of the ...
WebIn this study, we evaluated the in vitro antitumor activity of dialkylamino-1,4-naphthoquinones ( 1a–n) toward human glioblastoma multiforme cells (GBM02). All the … WebApr 9, 2024 · Clinopodium vulgare L. is a valuable medicinal plant used for its anti-inflammatory, antibacterial and wound-healing properties. The present study describes an efficient protocol for the micropropagation of C. vulgare and compares, for the first time, the chemical content and composition and antitumor and antioxidant activities of extracts …
WebApr 12, 2024 · In this study, we explored the combined antitumor activity of FAP-targeted and CLDN18.2-targeted CAR-T cells against PDAC. Novel FAP-targeted CAR-T cells were developed. ... With the successful selective attack on FAP-positive fibroblast in vitro, we evaluated whether FAP-mBBZ CAR-T could eliminate CAFs in vivo. The mice were … WebMany therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One of these approaches is in situ antitumor therapy. This way, bacteria, antibodies, …
WebLSCP-2 showed significantly antitumor activity against the SGC-7901 and MCF-7 cell lines, LSCP-1 showed significantly antitumor activity only against SGC-7901 cell line, and two fractions did not show activity against A549 cell line. Overall, this study indicated that LSCP posseses potential to treat gastric cancer and breast cancer.
WebAug 31, 2005 · The in vitro antitumor activity of β-D-MPR and α-D-MPR was evaluated in a panel of five human tumor cell lines (A121 ovarian carcinoma, A549 non-small cell lung carcinoma, HT-29 colon adenocarcinoma, MCF7-S breast adenocarcinoma and MCF7-R adriamycin resistant breast adenocarcinoma) as described . statistical analysis were performedWebFeb 4, 2024 · A simple synthetic pathway to Au–NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NR 1 R 2)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported.The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A … statistical analysis was performed usingWebThe activity of compound 4c was greater than that of compound 4b and more than that of the reference antitumor 5-flourouracil against the SW480, HCT116, and MCF-7 tumor cell … statistical analyst jobWebSep 26, 2013 · Chu, J., Deng, Y., Benson, D. et al. CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma. statistical analysis meaning in researchstatistical analysis was performed using spssWebFeb 1, 2024 · In vitro activity of selected compounds against ten cell lines. a IC 50 values were presented as the concentration of drug inhibition 50% cell growth and determined by at least three separate tests and reported. The IC 50 values were compared with those of Etoposide and 1a ( Table 2 ). statistical analysis vs predictive analysisWebOct 10, 2024 · The antitumor activity of some of spiro-tryptanthrin derivatives against erythroleukemia (K562), cervical carcinoma (HeLa) and colon carcinoma (CT26) cell lines was evaluated in vitro by MTS-assay ... statistical analysis tools for forecasting