WebASCVD was defined as myocardial infarction, coronary heart disease-related death, or fatal or nonfatal stroke. Results Of 6,814 MESA participants not prescribed statins at baseline, 5,185 had complete data and were included in this analysis. Their mean age was 61 years; 53.1% were women, 9.8% had diabetes, and 13.6% were current smokers. WebPhosphoinositides play an integral role in a diverse array of cellular signaling processes. Although considerable effort has been directed toward characterizing the kinases that produce inositol lipid second messengers, the study of phosphatases that oppose these kinases remains limited. Current research is focused on the identification of novel lipid …
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WebJun 23, 2011 · Myotubularin related protein 2 (MTMR2) is a member of the myotubularin family of phosphoinositide lipid phosphatases. Although MTMR2 dephosphorylates the phosphoinositides PI(3)P and PI(3,5)P2, the phosphoinositide binding proteins that are regulated by MTMR2 are poorly characterized. In this study, phosphoinositide affinity … WebJan 15, 2008 · Myotubularin-related protein 12 Alternative names Inactive phosphatidylinositol 3-phosphatase 12 Curated Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit ( 3-PAP; 3-phosphatase adapter protein) Gene names Name MTMR12 Synonyms KIAA1682, PIP3AP Organism names Organism Homo sapiens … bus hire richmond
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WebApr 13, 2016 · The MTM1 gene creates (encodes) a protein known as myotubularin. This protein is believed to be critical for the proper development, maintenance, and function of muscle tissue. ... one primary autosomal dominant form has been identified and is known as DNM2-related CNM. Three autosomal recessive forms have been identified and are … Myotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain InterPro: IPR004182. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associat… WebJan 15, 2011 · We also describe a working model to explain how MTMR2 interacts with other proteins such as c-Src, dynamin 2, EPS8 (growth factor receptor pathway substrate 8) and … handicap parking permit application oregon