2024 Roles of yap/taz in ferroptosis

Roles of yap/taz in ferroptosis

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August undefined, 2024

Web11 Jun 2024 · This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic... Web18 Aug 2024 · Mammalian TEAD proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. The Hippo pathway plays an essential role in controlling organ size and maintaining tissue homeostasis. Downstream from the Hippo …

Yiyu Dong, PHD - Associate Director/ Head of Early Phase

Web7 Jan 2024 · At the same time, YAP/TAZ sustain the protein stability, nuclear localization and transcriptional activity of ATF4 which in turn cooperates to induce SLC7A11 expression. Our study uncovered a critical role of YAP/TAZ in the repression of ferroptosis and thus in … WebThis article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer. Keywords ferroptosis Hippo … hella jumbo

Raquel Maeso Díaz Ph.D. - Postdoctoral Researcher - Duke …

WebPreviously, we identified TAZ, a Hippo pathway effector, regulates ferroptosis in renal and ovarian cancer cells. Because YAP (Yes-associated protein 1) is the one and only paralog of TAZ, sharing high sequence similarity and functional redundancy with TAZ, we tested the … WebFerroptosis is a novel form of programmed cell death characterized by the accumulation of lipid peroxidation. It can be induced by the oxidative stress caused by starvation of cystine, inhibition of glutathione peroxidase 4, or activation of NADPH oxidase(s). The canonical … Web18 May 2024 · Therefore, dysregulation of YAP/TAZ blocking apoptosis81 provides the mechanistic underpinning of their associations with the treatment resistance, recurrence and tumor dormancy.83 In comparison, much remains elusive about the biological … hellajulia

Biomarkers and Candidate Therapeutic Drugs in Heart Failure IJGM

Roles of YAP/TAZ in ferroptosis - PubMed

Web1 Sep 2024 · YAP/TAZ do not always induce ferroptosis: their roles in ferroptosis are cell context specific. In sorafenib (a chemotherapeutic drug) resistant hepatocellular carcinoma cells, YAP/TAZ form complexes with activating transcription factor 4 (ATF4) and induce … Web16 Mar 2024 · Figure 5 Molecular roles of circRNAs in the Hippo signaling pathway.The Hippo pathway is an evolutionarily conserved signaling pathway with key roles in various diseases, most notably cancer.The Hippo kinase cascade converges on its nuclear … hella k33375Web22 Jun 2024 · Functional analysis showed that Hippo members mutations were associated with higher nuclear accumulation of YAP/TAZ, core effectors of the Hippo pathway. ... Including Ferroptosis, and Cooperates ... hella k13396

"Web18 May 2024 · This review will provide an overview of the progress and current strategies to directly and indirectly target the YAP1/TAZ protein–protein interaction (PPI) with TEAD1–4 across multiple modalities, with focus on recent small molecules able to selectively bind … " - Roles of yap/taz in ferroptosis

Roles of yap/taz in ferroptosis

Context-dependent roles of YAP/TAZ in stem cell fates and cancer

Web1 Sep 2024 · Hippo pathway in ferroptosis. The Hippo pathway controls tissue growth, organ size, and development by regulating cell proliferation and self-renewal. The Hippo pathway is composed of core kinases: mammalian Ste20-like kinases 1/2 (MST1/2), large … Web13 Feb 2024 · YAP and TAZ are effectors of the Hippo pathway, functioning as transcriptional co-regulators that play roles in various cellular contexts. YAP was initially recognized for its roles in inducing hepatomegaly and apoptosis resistance in mice and …

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Web31 Aug 2024 · GAO R, KALATHUR R, COTO-LLERENA M, et al. YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis[J]. EMBO Mol Med, 2024, 13(12): e14351. DOI: 10.15252/emmm.202414351. WebFormation of YAP/TAZ-TEAD complexes leads to the transcription of growth-promoting genes. The abnormal activation of YAP/TAZ has been associated with multiple types of cancers. The main focus of this project is to investigate how the Hippo pathway regulates …

Web26 Oct 2024 · In this review, we discussed the regulatory role of ferroptosis on cancer progression and immunotherapy. Fig. 1: Regulating pathways of ferroptosis. TFR1 triggers iron uptake, which is... WebSodium-glucose cotransporter 2 (SGLT2) is highly expressed in RPTCs, but its relationship with YAP/TAZ in tubulointerstitial fibrosis ... From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance.

Web1 Dec 2024 · Long non-coding RNAs (lncRNAs) are a class of RNA transcripts that are longer than 200 nucleotides and have no apparent coding potential [8]. However, lncRNAs play a critical role in regulating the expression of many genes at the transcriptional, post … Web7 Dec 2024 · To further elaborate on the role of YAP and TAZ in supporting cell viability upon Sorafenib treatment of Sorafenib‐resistant HCC cells, we further employed the Promega Celltiter Glo TM assay which confirmed the conclusion that YAP/TAZ promotes …

Web10 Dec 2024 · The YAP/TAZ target genes encode proteins involved in the signaling relay and amplification to affect lipid/iron metabolism ( ACSL4: acyl-CoA synthetase long-chain family member 4/ TFRC: transferrin receptor) or reactive oxygen species (ROS) productions …

Web3 Sep 2024 · The role of YAP/TAZ in glucose metabolism YAP/TAZ in anaerobic glycolysis. Unlike normal cells, tumor cells rely mainly on glycolysis to provide energy and substances necessary for sustained cell proliferation, even under normoxic conditions, which is called … hellajuneteenthWeb1 May 2024 · The evolutionarily conserved Hippo pathway effector YAP/TAZ, which is highly resistant to ferroptosis when grown in fusion conditions, can sense and regulate the densitydependent phenotype in... hella k12741 hella k 3231WebGAO R, KALATHUR R, COTO-LLERENA M, et al. YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis[J]. EMBO Mol Med, 2024, 13(12): e14351. DOI: 10.15252/emmm.202414351. [7] ZHOU YY, ZHAO XX, CHEN YY, et … hella k23269Web18 Dec 2024 · Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic malignancies has drawn considerable … hella k21601Web1 May 2024 · The YAP/TAZ activation under low density, while confers apoptosis resistance, renders cancer cells sensitivity to ferroptosis. These findings establish YAP/TAZ and Hippo pathways as novel determinants of ferroptosis. Therefore, inducing ferroptosis may have … hella k13234http://lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2024.04.015 hella kassettenmarkise cleo