Statins scholar
WebSep 2, 2024 · HMG-CoA reductase inhibitors (statins) are lipid-lowering medications used in the primary and secondary prevention of coronary heart disease. Atorvastatin … WebMay 29, 2024 · Statin use was 7% in the optimal group, 24% in the borderline group, 46% in the elevated and decreasing group, and 91% in the highest group. Consistent with many other Framingham analyses, high‐density lipoprotein …
Statins scholar
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WebGoogle Scholar. 2. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344: 1383-1389. Crossref ... WebNov 13, 2024 · Statins are widely prescribed cholesterol-lowering drugs that inhibit HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate metabolic pathway. Multiple lines of evidence indicate that certain cancers depend on the mevalonate pathway for growth and survival, and, therefore, are vulnerable to statin therapy.
WebJun 1, 2009 · 4 Amarenco P, Labreuche J. Lipid management and stroke. Lancet Neurol 2009; 8:453–63. 5 Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005; 366:1267–78 (Erratum in: Lancet 2005; … WebJul 27, 2024 · Most studies suggested a positive effect of statins on the occurrence and severity of depression, with fewer studies showing no effect, while a minority indicated …
WebJun 13, 2024 · A meta-analysis with 91140 participants covering 13 statins showed that statin therapy was associated with a 9% increased risk for incident DM ( Sattar et al., 2010 ). In the SPARCL trial, a population with statin treatment had an 11% higher risk of DM than the placebo group. Moreover, Culver et al. reported a 48% increase in the risk of new ... WebStatins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of …
WebOct 6, 2004 · The level of serum cholesterol considered acceptable was pegged at about 240 mg/dL. With the advent of statins, it became possible to lower LDL levels by 50% or more. As a result, the target levels have changed dramatically with the demonstration that lowering cholesterol to ever-diminishing levels with the use of statins prevents heart …
WebTo help clinicians individualize statin therapy for primary prevention in older adults, we conducted a survival meta-analysis of the major randomized clinical trials to determine … morgantown wv trick or treat 2021WebJul 14, 2024 · Statins are the first-line pharmaceutical agent in the management of hypercholesterolemia and cardiovascular (CV) risk reduction, and the most commonly … morgantown wv to ravenswood wvWebBrand-name statins were used by 18.2% of statin users, accounting for 55% of total costs in 2012-2013. Conclusion and Relevance Statin use increased substantially in the last decade among US adults, although the uptake was suboptimal in high-risk groups. While total and OOP expenditures associated with statins decreased, further substitution of ... morgantown wv to rock hill scWebNov 30, 2024 · Experimental evidence suggests that statin treatment may reduce perihematomal cell death and improve recovery after brain hemorrhage, even when statins are administered after the event. 44 – 46 There is growing evidence from clinical studies corroborating these preclinical observations ( Table 1 ). 14, 16, 18, 19, 26, 47 Flint et al 18 … morgantown wv to weston wvWebJul 14, 2024 · Statins are the first-line pharmaceutical agent in the management of hypercholesterolemia and cardiovascular (CV) risk reduction, and the most commonly prescribed class of drugs worldwide. Studies describing CV risk reduction independent of LDL-cholesterol lowering have evoked an interest in the pleiotropic mechanisms of … morgantown wv trick or treat 2022WebFeb 1, 2008 · Muscle problems. Statins commonly cause muscle pain (myalgia). Rarely, statin use can lead to rhabdomyolysis — severe muscle deterioration, with the release of … morgantown wv to pigeon forge tnWebAug 1, 2013 · Statin-treated diabetes patients had a 22% (95% CI 13–30%) relative risk reduction (event rate 20.2 vs. 25.1%). Similar reductions were seen in those without baseline occlusive arterial disease and those with baseline LDL cholesterol levels < 116 mg/dl. 14 Table 1. Summary of Nine Primary Prevention Trials in Diabetes View large morgantown wv to salem oh